Block Periodization - Why Targeting One Physiological System at a Time Leads to Better Adaptation

The above presentation is best viewed/played on a computer.

____________________

At QT2 we have always believed in purposeful training rooted in science and driven by the principle of adaptation. As we transition into QT2.0, one of the foundational strategies behind our coaching approach is block periodization—a method that focuses on training a single physiological system at a time.

But why is this strategy so effective? Why not train everything, all the time?

The answer lies in how the human body adapts to stress. Your body doesn’t have unlimited adaptive bandwidth. Trying to improve multiple physiological systems simultaneously—like aerobic capacity, lactate threshold, neuromuscular power, and muscular strength—often leads to diluted signals, inefficient recovery, and suboptimal results. By narrowing the focus to a single system within a block of training, we create the conditions necessary for meaningful, lasting adaptation.

Here’s how that works in practice:


The Problem with Training Everything at Once

Think of your body as a team of specialized workers with limited time and resources. If you ask them to build a house, fix a car, and plant a garden all at once, nothing gets done particularly well. The same principle applies to training. When you simultaneously target multiple systems, you’re spreading your adaptive capacity too thin.

This is known as the interference effect: competing molecular and systemic demands compromise your body’s ability to respond effectively to any single training stimulus.


Why System-Focused Training Works Better

1. Clearer Molecular Signaling = Deeper Adaptation
Different training types activate distinct molecular pathways. Threshold work, for instance, stimulates increases in lactate transporters (MCT1, MCT4) and mitochondrial density. VO₂ Max intervals, on the other hand, elevate cardiovascular output and oxygen delivery mechanisms. By concentrating on one system for several weeks, these signals compound, producing more complete and durable adaptations.

2. Reduced Interference Between Conflicting Pathways
Some adaptations are biologically antagonistic. For example, endurance training activates the AMPK pathway, while strength training stimulates mTOR—two pathways that can inhibit one another when simultaneously activated. Isolating your training focus minimizes this biochemical tug-of-war, allowing each adaptation to develop to its full potential.

3. Recovery Strategies Can Be Matched to the Stress
Every training stress comes with a specific recovery need. VO₂ Max sessions deplete glycogen and challenge your central nervous system, while muscular endurance work may create greater structural damage. When training is focused, recovery can be too—allowing nutrition, sleep, and ancillary work to align with the demands of that specific block.

4. Greater Mental Clarity and Motivation
Focused training sharpens your psychological engagement. When you know, “This month is about improving threshold,” every session has a purpose. Clarity breeds motivation, and motivation fuels consistency—arguably the most important factor in long-term athletic development.

5. Progress Becomes Visible and Measurable
When training has a singular focus, performance gains in that area become more obvious. These measurable improvements feed back into the training loop, providing motivation and helping coaches make informed decisions about when to shift focus to the next physiological system.


Supported by Research—and by Results

Block periodization isn’t just theory. Numerous studies and years of athlete data support the idea that focused blocks of training followed by recovery lead to superior long-term gains—especially in experienced athletes. As training age increases, so too does the need for targeted, high-quality stimuli to provoke meaningful adaptation.


The QT2.0 Takeaway

Focusing on one system at a time may feel, at first, like you’re ignoring other components of your fitness. In truth, you’re enabling deeper, more efficient growth. By giving your body a clear directive, and the time and space to respond to it, you accelerate your development as an athlete.

So whether a training plan leans into threshold, aerobic durability, VO₂ Max, or neuromuscular economy—trust the process. It's not about doing everything—it's about doing the right thing at the right time.

Back to blog
1 of 4